000008759 001__ 8759
000008759 005__ 20231129124948.0
000008759 0247_ $$2DOI$$a10.6083/vm40xs28m
000008759 037__ $$aETD
000008759 245__ $$aPlatelet signaling in hemostasis and vascular inflammation
000008759 260__ $$bOregon Health and Science University
000008759 269__ $$a2021
000008759 336__ $$aDissertation
000008759 502__ $$bPh.D.
000008759 520__ $$aFormation of a hemostatic clot is essential for minimizing blood loss upon injury and is mediated, in part, by tightly regulated activity of and crosstalk between platelets and plasma proteases of blood coagulation. Dysregulation of this otherwise protective clotting mechanism provokes thrombosis, which is caused by pathologic intravascular progression of some hemostatic mechanisms, and manifests as the common underlying pathology of major cardiovascular diseases. There remains an unmet clinical need for safer therapeutics that are effective while also preserving hemostasis. The present research defines signaling mechanisms underlying the role of platelet and coagulation proteases in hemostasis and vascular inflammation.
000008759 542__ $$fIn copyright - single owner
000008759 650__ $$aInflammation$$020800
000008759 650__ $$aBlood Coagulation$$015652
000008759 650__ $$aBlood Platelets$$015667
000008759 650__ $$aThrombosis$$027034
000008759 650__ $$aHemostasis$$020090
000008759 650__ $$aAtherosclerosis$$036329
000008759 691__ $$aSchool of Medicine$$041369
000008759 692__ $$aDepartment of Biomedical Engineering$$041397
000008759 7001_ $$aNgo, Anh
000008759 8564_ $$980296a71-b19a-4ab7-8168-5010f9becb6d$$s29143645$$uhttps://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
000008759 905__ $$a/rest/prod/vm/40/xs/28/vm40xs28m
000008759 909CO $$ooai:digitalcollections.ohsu.edu:8759$$pstudent-work
000008759 980__ $$aTheses and Dissertations