000000876 001__ 876
000000876 005__ 20250306135933.0
000000876 0247_ $$2DOI$$a10.6083/M4DR2SH4
000000876 037__ $$aETD
000000876 245__ $$aIntegrated signatures of disease using network methods
000000876 260__ $$bOregon Health and Science University
000000876 269__ $$a2012
000000876 336__ $$aDissertation
000000876 502__ $$bPh.D.
000000876 502__ $$gBiomedical Informatics
000000876 520__ $$aCo-expression network models help identify important biochemical pathways, biomarkers, and targets for research, but they typically focus on gene expression. In this work, co-expression network methodologies are extended to proteomics and applied to data derived from mice infected with either influenza or SARS-CoV. This work develops the methods necessary for deriving integrated network signatures of disease with an application in systems biology of infectious disease.
000000876 540__ $$fCC BY
000000876 542__ $$fIn copyright - single owner
000000876 650__ $$aTranscriptome$$039582
000000876 650__ $$aGene Regulatory Networks$$037326
000000876 650__ $$aProteome$$032481
000000876 650__ $$aProtein Interaction Maps$$039690
000000876 650__ $$aProteomics$$035059
000000876 650__ $$aSystems Biology$$036214
000000876 650__ $$aCommunicable Diseases$$016934
000000876 650__ $$aMice$$036842
000000876 650__ $$aInfluenza, Human$$020802
000000876 650__ $$aSevere acute respiratory syndrome-related coronavirus$$035648
000000876 650__ $$aBiomarkers$$028395
000000876 6531_ $$abiochemical markers
000000876 6531_ $$aprotein-protein interaction
000000876 691__ $$aSchool of Medicine$$041369
000000876 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000000876 7001_ $$aGibbs, David$$uOregon Health and Science University$$041354
000000876 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000876 8564_ $$9f1d0c0fa-820b-468d-b2c5-597634e6e937$$s11153116$$uhttps://digitalcollections.ohsu.edu/record/876/files/879_etd.pdf
000000876 905__ $$a/rest/prod/1v/53/jx/05/1v53jx05d
000000876 909CO $$ooai:digitalcollections.ohsu.edu:876$$pstudent-work
000000876 980__ $$aBiomedical Informatics