000000877 001__ 877
000000877 005__ 20251209084450.0
000000877 0247_ $$2DOI$$a10.6083/M4930R50
000000877 037__ $$aETD
000000877 245__ $$aUncovering the role of T cells in the control of varicella zoster virus using simian varicella virus infection of rhesus macaques as a model
000000877 260__ $$bOregon Health and Science University
000000877 269__ $$a2013
000000877 336__ $$aDissertation
000000877 502__ $$bPh.D.
000000877 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000000877 520__ $$aVaricella zoster virus (VZV), the cause of chickenpox and shingles, establishes latency in sensory ganglia and reactivates with immune decline, leading to significant morbidity. Current vaccines provide only short-term immunity, highlighting the need for improved strategies. Using simian varicella virus (SVV) infection in rhesus macaques as a model, we investigated cellular immunity in viral resolution. Our findings reveal critical roles for CD4 and CD8 T cells, including cytotoxic and cytokine functions, and implicate plasmacytoid dendritic cells in early responses. Immune depletion confirmed cellular immunity as essential for SVV control. These results advance understanding of adaptive immunity and inform vaccine development.
000000877 540__ $$fCC BY
000000877 542__ $$fIn copyright - single owner
000000877 650__ $$aMacaca mulatta$$021724
000000877 650__ $$aImmune System Phenomena$$038405
000000877 650__ $$aT-Lymphocytes$$026731
000000877 650__ $$aVaricellovirus$$030539
000000877 650__ $$aVaccine Development$$013568
000000877 650__ $$aImmunity, Cellular$$020670
000000877 650__ $$aHerpesvirus 3, Human$$027725
000000877 650__ $$aVaricella Zoster Virus Infection$$012181
000000877 650__ $$aCD8-Positive T-Lymphocytes$$030782
000000877 6531_ $$arhesus monkey
000000877 6531_ $$asimian viruses
000000877 691__ $$aSchool of Medicine$$041369
000000877 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000877 7001_ $$aHaberthur, Kristen$$uOregon Health and Science University$$041354
000000877 7201_ $$aMessaoudi, Ilhem$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000877 8564_ $$931e43fbb-4bd5-4a17-bc17-13a6f3b4b796$$s15754331$$uhttps://digitalcollections.ohsu.edu/record/877/files/880_etd.pdf$$ePublic$$2f1009a79b97b77925a5ce5fa47c4ec9b$$31
000000877 905__ $$a/rest/prod/pc/28/9j/08/pc289j08t
000000877 909CO $$ooai:digitalcollections.ohsu.edu:877$$pstudent-work
000000877 980__ $$aTheses and Dissertations