@article{ETD, recid = {8795}, author = {Sanford-Crane, Hannah S.}, title = {Characterization of a novel GOT2-PPARδ axis in pancreatic ductal adenocarcinoma}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2021}, number = {ETD}, abstract = {This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive phenotype of tumor-infiltrating myeloid cells. The immune-suppressive pathophysiology of PDAC has been linked to poor patient prognosis and makes most PDAC patients unresponsive to immune-therapies which have proven highly effective in cancers with improved T cell penetrance. Our results suggest that the GOT2-PPARδ axis could be a key player in the development of this immunological hallmark of PDAC.}, url = {http://digitalcollections.ohsu.edu/record/8795}, doi = {https://doi.org/10.6083/6d56zx322}, }