TY  - GEN
N2  - This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive phenotype of tumor-infiltrating myeloid cells. The immune-suppressive pathophysiology of PDAC has been linked to poor patient prognosis and makes most PDAC patients unresponsive to immune-therapies which have proven highly effective in cancers with improved T cell penetrance. Our results suggest that the GOT2-PPARδ axis could be a key player in the development of this immunological hallmark of PDAC.
DO  - 10.6083/6d56zx322
DO  - DOI
AB  - This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive phenotype of tumor-infiltrating myeloid cells. The immune-suppressive pathophysiology of PDAC has been linked to poor patient prognosis and makes most PDAC patients unresponsive to immune-therapies which have proven highly effective in cancers with improved T cell penetrance. Our results suggest that the GOT2-PPARδ axis could be a key player in the development of this immunological hallmark of PDAC.
T1  - Characterization of a novel GOT2-PPARδ axis in pancreatic ductal adenocarcinoma
DA  - 2021
AU  - Sanford-Crane, Hannah S.
L1  - https://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 8795
L4  - https://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
KW  - Tumor Microenvironment
KW  - Pancreatic Neoplasms
KW  - Peroxisome Proliferator-Activated Receptors
KW  - got2
TI  - Characterization of a novel GOT2-PPARδ axis in pancreatic ductal adenocarcinoma
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
ER  -