000008795 001__ 8795
000008795 005__ 20240124114309.0
000008795 0247_ $$2DOI$$a10.6083/6d56zx322
000008795 037__ $$aETD
000008795 245__ $$aCharacterization of a novel GOT2-PPARδ axis in pancreatic ductal adenocarcinoma
000008795 260__ $$bOregon Health and Science University
000008795 269__ $$a2021
000008795 336__ $$aDissertation
000008795 502__ $$bPh.D.
000008795 520__ $$aThis cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive phenotype of tumor-infiltrating myeloid cells. The immune-suppressive pathophysiology of PDAC has been linked to poor patient prognosis and makes most PDAC patients unresponsive to immune-therapies which have proven highly effective in cancers with improved T cell penetrance. Our results suggest that the GOT2-PPARδ axis could be a key player in the development of this immunological hallmark of PDAC.
000008795 542__ $$fIn copyright - single owner
000008795 650__ $$aTumor Microenvironment$$039473
000008795 650__ $$aPancreatic Neoplasms$$023517
000008795 650__ $$aPeroxisome Proliferator-Activated Receptors$$035968
000008795 6531_ $$agot2
000008795 691__ $$aSchool of Medicine$$041369
000008795 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000008795 7001_ $$aSanford-Crane, Hannah S.
000008795 8564_ $$9a7277edc-63d4-443f-8f14-7e61234c3bc5$$s5281345$$uhttps://digitalcollections.ohsu.edu/record/8795/files/SanfordCrane.Hannah.2021.pdf
000008795 905__ $$a/rest/prod/6d/56/zx/32/6d56zx322
000008795 909CO $$ooai:digitalcollections.ohsu.edu:8795$$pstudent-work
000008795 980__ $$aTheses and Dissertations