@article{ETD,
      recid = {881},
      author = {Mo, Weike},
      title = {Hearing in zebrafish: from mechanotransduction to synaptic  transmission},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2013},
      number = {ETD},
      abstract = {Zebrafish serve as a key model for auditory and vestibular  research. We developed a novel method to quantify  vestibular defects in larvae using the vestibulo-ocular  reflex, demonstrating functional eye movements by 72 hours  post-fertilization dependent on anterior/utricular otolith  organs. Investigating synaptic mechanisms, we identified a  point mutation (nsfI209N) that impairs synaptic  transmission without altering ribbon synapse structure,  while nsf null mutations cause synaptic degeneration. Nsf  activity is essential for ribbon synapse maintenance, and  Vamp2/Vamp8 were detected in hair cells, suggesting  non-conventional SNARE-mediated transmission. Additionally,  a yeast two-hybrid screen identified Tmc2a as a candidate  mechanotransduction partner for Pcdh15a, warranting further  study.},
      url = {http://digitalcollections.ohsu.edu/record/881},
      doi = {https://doi.org/10.6083/M4S180H2},
}