000008812 001__ 8812
000008812 005__ 20240124114310.0
000008812 0247_ $$2DOI$$a10.6083/vd66w0581
000008812 037__ $$aETD
000008812 245__ $$aLeptin signaling in pancreatic B-cells: a mechanism to regulate KATP channel trafficking and B-cell electrical activity
000008812 260__ $$bOregon Health and Science University
000008812 269__ $$a2021
000008812 336__ $$aDissertation
000008812 502__ $$bPh.D.
000008812 520__ $$aInsulin is a hormone secreted by pancreatic B-cells in response to glucose stimulation. Proper insulin secretion keeps blood glucose in a physiological range by promoting the uptake of glucose by insulin-sensitive target tissues. In addition to glucose, various other metabolic and hormonal stimuli act on B-cells to modulate insulin secretion and maintain metabolic homeostasis. In this thesis, leptin is shown to induce a Ca2+ influx via Src kinase potentiation of N-Methyl-D-Aspartate (NMDA) receptors that initiates the CaMKK?-AMPK signaling pathways.
000008812 542__ $$fIn copyright - single owner
000008812 650__ $$aLeptin$$032651
000008812 650__ $$aDiabetes Mellitus$$017671
000008812 650__ $$aA Kinase Anchor Proteins$$038018
000008812 650__ $$aKATP Channels$$037700
000008812 6531_ $$anmda receptors
000008812 6531_ $$aprotein kinase a
000008812 691__ $$aSchool of Medicine$$041369
000008812 7001_ $$aCochrane, Veronica
000008812 8564_ $$92d454927-ffdf-45a1-b547-a12ad5e932c4$$s6373228$$uhttps://digitalcollections.ohsu.edu/record/8812/files/Cochrane.Veronica.2021.pdf
000008812 905__ $$a/rest/prod/vd/66/w0/58/vd66w0581
000008812 909CO $$ooai:digitalcollections.ohsu.edu:8812$$pstudent-work
000008812 980__ $$aTheses and Dissertations