@article{ETD,
      school = {Ph.D.},
      author = {Joshi, Sunil K.},
      url = {http://digitalcollections.ohsu.edu/record/8850},
      title = {Targeting receptor tyrosine kinases in leukemia: from  identification of new targets to overcoming mechanisms of  resistance},
      publisher = {Oregon Health and Science University},
      abstract = {Preponderant genomic sequencing and clinical evidence have  revealed the remarkable heterogeneity that underpins  leukemia. Such efforts have brought to the forefront new  oncogenic alterations and mechanisms of drug resistance.  This dissertation is focused on the identification and  characterization of intrinsic and extrinsic mechanisms of  receptor tyrosine kinase (RTK) activation in the setting of  leukemia. An understanding of these mechanisms can be  harnessed clinically to facilitate the development of new  therapies and, thereby expand the promise of precision  medicine. This work implicates that disrupting the  crosstalk between leukemia cells and the marrow  microenvironment could circumvent drug resistance and  improve patient outcomes.},
      number = {ETD},
      doi = {https://doi.org/10.6083/rr171x85d},
      recid = {8850},
      address = {2021},
}