TY  - GEN
N2  - Preponderant genomic sequencing and clinical evidence have revealed the remarkable heterogeneity that underpins leukemia. Such efforts have brought to the forefront new oncogenic alterations and mechanisms of drug resistance. This dissertation is focused on the identification and characterization of intrinsic and extrinsic mechanisms of receptor tyrosine kinase (RTK) activation in the setting of leukemia. An understanding of these mechanisms can be harnessed clinically to facilitate the development of new therapies and, thereby expand the promise of precision medicine. This work implicates that disrupting the crosstalk between leukemia cells and the marrow microenvironment could circumvent drug resistance and improve patient outcomes.
DO  - 10.6083/rr171x85d
DO  - DOI
AB  - Preponderant genomic sequencing and clinical evidence have revealed the remarkable heterogeneity that underpins leukemia. Such efforts have brought to the forefront new oncogenic alterations and mechanisms of drug resistance. This dissertation is focused on the identification and characterization of intrinsic and extrinsic mechanisms of receptor tyrosine kinase (RTK) activation in the setting of leukemia. An understanding of these mechanisms can be harnessed clinically to facilitate the development of new therapies and, thereby expand the promise of precision medicine. This work implicates that disrupting the crosstalk between leukemia cells and the marrow microenvironment could circumvent drug resistance and improve patient outcomes.
T1  - Targeting receptor tyrosine kinases in leukemia: from identification of new targets to overcoming mechanisms of resistance
DA  - 2021
AU  - Joshi, Sunil K.
L1  - https://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 8850
L4  - https://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
KW  - Leukemia
KW  - Drug Resistance
KW  - point mutations
KW  - tyrosine kinase inhibitor
KW  - cancer
KW  - tyrosine kinase receptors
TI  - Targeting receptor tyrosine kinases in leukemia: from identification of new targets to overcoming mechanisms of resistance
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
ER  -