000008850 001__ 8850
000008850 005__ 20240124114311.0
000008850 0247_ $$2DOI$$a10.6083/rr171x85d
000008850 037__ $$aETD
000008850 245__ $$aTargeting receptor tyrosine kinases in leukemia: from identification of new targets to overcoming mechanisms of resistance
000008850 260__ $$bOregon Health and Science University
000008850 269__ $$a2021
000008850 336__ $$aDissertation
000008850 502__ $$bPh.D.
000008850 520__ $$aPreponderant genomic sequencing and clinical evidence have revealed the remarkable heterogeneity that underpins leukemia. Such efforts have brought to the forefront new oncogenic alterations and mechanisms of drug resistance. This dissertation is focused on the identification and characterization of intrinsic and extrinsic mechanisms of receptor tyrosine kinase (RTK) activation in the setting of leukemia. An understanding of these mechanisms can be harnessed clinically to facilitate the development of new therapies and, thereby expand the promise of precision medicine. This work implicates that disrupting the crosstalk between leukemia cells and the marrow microenvironment could circumvent drug resistance and improve patient outcomes.
000008850 542__ $$fIn copyright - single owner
000008850 650__ $$aLeukemia$$021430
000008850 650__ $$aDrug Resistance$$018079
000008850 6531_ $$apoint mutations
000008850 6531_ $$atyrosine kinase inhibitor
000008850 6531_ $$acancer
000008850 6531_ $$atyrosine kinase receptors
000008850 691__ $$aSchool of Medicine$$041369
000008850 692__ $$aDepartment of Physiology and Pharmacology$$041442
000008850 7001_ $$aJoshi, Sunil K.
000008850 8564_ $$9f166ef8a-ae5f-445c-8107-875957af5d0a$$s144020895$$uhttps://digitalcollections.ohsu.edu/record/8850/files/Joshi.Sunil.2021.pdf
000008850 905__ $$a/rest/prod/rr/17/1x/85/rr171x85d
000008850 909CO $$ooai:digitalcollections.ohsu.edu:8850$$pstudent-work
000008850 980__ $$aTheses and Dissertations