TY - GEN AB - PARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a process known as ADP-ribosylation. Identifying the protein substrates of an individual PARP family member is essential for understanding its cellular role; however, doing so remained an impracticable task until the development of chemical genetic strategies. AU - Rodriguez, Kelsie M. DA - 2021 DO - 10.6083/707958363 DO - DOI ID - 8886 KW - Proteomics KW - Cysteine KW - ADP-Ribosylation KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin KW - poly(adp-ribose) polymerase KW - innate immunity L1 - https://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf L2 - https://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf L4 - https://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf LK - https://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf N2 - PARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a process known as ADP-ribosylation. Identifying the protein substrates of an individual PARP family member is essential for understanding its cellular role; however, doing so remained an impracticable task until the development of chemical genetic strategies. PB - Oregon Health and Science University PY - 2021 T1 - Chemical tools for the elucidation of the role of PARP7 in the innate immune system TI - Chemical tools for the elucidation of the role of PARP7 in the innate immune system UR - https://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf Y1 - 2021 ER -