000008886 001__ 8886
000008886 005__ 20240124114312.0
000008886 0247_ $$2DOI$$a10.6083/707958363
000008886 037__ $$aETD
000008886 245__ $$aChemical tools for the elucidation of the role of PARP7 in the innate immune system
000008886 260__ $$bOregon Health and Science University
000008886 269__ $$a2021
000008886 336__ $$aDissertation
000008886 502__ $$bPh.D.
000008886 520__ $$aPARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a process known as ADP-ribosylation. Identifying the protein substrates of an individual PARP family member is essential for understanding its cellular role; however, doing so remained an impracticable task until the development of chemical genetic strategies.
000008886 542__ $$fIn copyright - single owner
000008886 650__ $$aProteomics$$035059
000008886 650__ $$aCysteine$$017310
000008886 650__ $$aADP-Ribosylation$$012404
000008886 6531_ $$a2,3,7,8-tetrachlorodibenzo-p-dioxin
000008886 6531_ $$apoly(adp-ribose) polymerase
000008886 6531_ $$ainnate immunity
000008886 691__ $$aSchool of Medicine$$041369
000008886 7001_ $$aRodriguez, Kelsie M.
000008886 8564_ $$95b28a811-7c75-4357-8da5-53d555b45f0b$$s58678770$$uhttps://digitalcollections.ohsu.edu/record/8886/files/Rodriguez.Kelsie.2021.pdf
000008886 905__ $$a/rest/prod/70/79/58/36/707958363
000008886 909CO $$ooai:digitalcollections.ohsu.edu:8886$$pstudent-work
000008886 980__ $$aTheses and Dissertations