000000892 001__ 892
000000892 005__ 20251216153541.0
000000892 0247_ $$2DOI$$a10.6083/M4BV7DNP
000000892 037__ $$aETD
000000892 245__ $$aHyaluronan and its degradation products have opposing effects on experimental autoimmune encephalomyelitis pathogenesis that are dependent and independent of CD44
000000892 260__ $$bOregon Health and Science University
000000892 269__ $$a2012
000000892 336__ $$aDissertation
000000892 502__ $$bPh.D.
000000892 520__ $$aMultiple sclerosis (MS) involves immune-mediated demyelination and axonal damage, driven by CD4+ T-cell infiltration across the blood-brain barrier (BBB). This work examines the role of hyaluronan (HA) and its receptor CD44 in T-cell capture and rolling on CNS endothelial cells, a key step in extravasation. High-molecular-weight HA tethered by CD44 promoted lymphocyte rolling, while enzymatic HA removal delayed disease onset in EAE models. Surprisingly, HA oligosaccharides (HA12) also reduced disease severity and impaired lymphocyte rolling independently of CD44 or TLR4. These findings identify HA size-specific effects as potential therapeutic targets for limiting immune cell entry in CNS inflammation.
000000892 540__ $$fCC BY
000000892 542__ $$fIn copyright - single owner
000000892 650__ $$aEndothelial Cells$$035222
000000892 650__ $$aMultiple Sclerosis$$022506
000000892 650__ $$aBlood-Brain Barrier$$015687
000000892 650__ $$aLymphocytes$$021689
000000892 650__ $$aCD4-Positive T-Lymphocytes$$028453
000000892 691__ $$aSchool of Medicine$$041369
000000892 7001_ $$aWinkler, Clayton$$uOregon Health and Science University$$041354
000000892 7201_ $$aSherman, Lawrence$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000892 8564_ $$9f83b3822-679a-49fd-82a1-8da731ee8ee4$$s4337762$$uhttps://digitalcollections.ohsu.edu/record/892/files/895_etd.pdf$$ePublic$$262884cc78da479ec581ef81a32d7520d$$31
000000892 905__ $$a/rest/prod/69/69/z0/81/6969z081q
000000892 909CO $$ooai:digitalcollections.ohsu.edu:892$$pstudent-work
000000892 980__ $$aTheses and Dissertations