TY - GEN AB - Single-cell methods have proven to be a powerful tool in the interrogation of complex biology. One such biological system in which single-cell methods have been paramount to the discovery of complex disease and cell development is in the mammalian cortex. In this thesis I present an overview of single-cell method development for chromatin accessibility, chromatin conformation, whole genome sequencing, and whole methylome sequencing. AU - Mulqueen, Ryan M. DA - 2021 DO - 10.6083/pv63g0880 DO - DOI ID - 8946 KW - Methylation KW - Cerebral Cortex KW - Nervous System KW - Chromatin L1 - https://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf L2 - https://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf L4 - https://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf LK - https://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf N2 - Single-cell methods have proven to be a powerful tool in the interrogation of complex biology. One such biological system in which single-cell methods have been paramount to the discovery of complex disease and cell development is in the mammalian cortex. In this thesis I present an overview of single-cell method development for chromatin accessibility, chromatin conformation, whole genome sequencing, and whole methylome sequencing. PB - Oregon Health and Science University PY - 2021 T1 - Novel single-cell omics assays of corticogenesis TI - Novel single-cell omics assays of corticogenesis UR - https://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf Y1 - 2021 ER -