000008946 001__ 8946 000008946 005__ 20231129124948.0 000008946 0247_ $$2DOI$$a10.6083/pv63g0880 000008946 037__ $$aETD 000008946 245__ $$aNovel single-cell omics assays of corticogenesis 000008946 260__ $$bOregon Health and Science University 000008946 269__ $$a2021 000008946 336__ $$aDissertation 000008946 502__ $$bPh.D. 000008946 520__ $$aSingle-cell methods have proven to be a powerful tool in the interrogation of complex biology. One such biological system in which single-cell methods have been paramount to the discovery of complex disease and cell development is in the mammalian cortex. In this thesis I present an overview of single-cell method development for chromatin accessibility, chromatin conformation, whole genome sequencing, and whole methylome sequencing. 000008946 542__ $$fIn copyright - single owner 000008946 650__ $$aMethylation$$022181 000008946 650__ $$aCerebral Cortex$$016362 000008946 650__ $$aNervous System$$022807 000008946 650__ $$aChromatin$$016651 000008946 691__ $$aSchool of Medicine$$041369 000008946 692__ $$aDepartment of Molecular and Medical Genetics$$041428 000008946 7001_ $$aMulqueen, Ryan M. 000008946 8564_ $$9e17bab65-c426-4a52-a64d-687eb7f6a471$$s7603165$$uhttps://digitalcollections.ohsu.edu/record/8946/files/Mulqueen.Ryan.2021.pdf 000008946 905__ $$a/rest/prod/pv/63/g0/88/pv63g0880 000008946 909CO $$ooai:digitalcollections.ohsu.edu:8946$$pstudent-work 000008946 980__ $$aTheses and Dissertations