000000896 001__ 896
000000896 005__ 20260120144840.0
000000896 0247_ $$2DOI$$a10.6083/M4TT4NZG
000000896 037__ $$aETD
000000896 245__ $$aGenetic and functional analysis of autosomal loci that control chromosome-wide DNA replication timing and monoallelic gene expression
000000896 260__ $$bOregon Health and Science University
000000896 269__ $$a2013
000000896 336__ $$aDissertation
000000896 502__ $$bPh.D.
000000896 502__ $$gCell & Developmental Biology (sunsetting)
000000896 520__ $$aHuman cancers often exhibit chromosomal abnormalities, many with unclear roles in carcinogenesis. Certain rearrangements show delayed replication timing (DRT) and delayed mitotic condensation (DMC), leading to instability and increased mutagenesis. The Thayer lab hypothesizes these effects result from disruption of cis-acting “inactivation/stability centers” (I/S centers) that regulate replication timing, condensation, and monoallelic expression. This work demonstrates that ASAR6, like Xist, disrupts replication timing and induces chromosome-wide silencing when ectopically integrated. Additionally, a novel locus on chromosome 15 was identified as essential for chromosomal stability. These findings support the existence of I/S centers on all mammalian chromosomes and their role in genome integrity.
000000896 540__ $$fCC BY
000000896 542__ $$fIn copyright - single owner
000000896 650__ $$aGenomics$$033016
000000896 650__ $$aDNA Replication$$017991
000000896 650__ $$aGene Expression$$028717
000000896 650__ $$aDNA Replication Timing$$035197
000000896 650__ $$aGenomic Instability$$035232
000000896 650__ $$aNeoplasms$$022758
000000896 650__ $$aChromosome Aberrations$$016677
000000896 650__ $$aChromosomes, Human, Pair 15$$016691
000000896 6531_ $$atumors
000000896 691__ $$aSchool of Medicine$$041369
000000896 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000896 7001_ $$aDonley, Nathan$$uOregon Health and Science University$$041354
000000896 7201_ $$aThayer, Mathew$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000896 8564_ $$93a022545-d124-49ba-bda9-289a412b4507$$s65395409$$uhttps://digitalcollections.ohsu.edu/record/896/files/899_etd.pdf$$ePublic$$28eef4ab7bafb931953ce63e1ea4c3515$$31
000000896 905__ $$a/rest/prod/6m/31/1p/34/6m311p341
000000896 909CO $$ooai:digitalcollections.ohsu.edu:896$$pstudent-work
000000896 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000896 980__ $$aTheses and Dissertations