000000897 001__ 897
000000897 005__ 20251229131910.0
000000897 0247_ $$2DOI$$a10.6083/M4Q23X8X
000000897 037__ $$aETD
000000897 245__ $$aRabconnectin3α promotes stable activity of the H+-pump on synaptic vesicles in hair cells
000000897 260__ $$bOregon Health and Science University
000000897 269__ $$a2012
000000897 336__ $$aDissertation
000000897 502__ $$bPh.D.
000000897 502__ $$gNeuroscience
000000897 520__ $$aThis thesis investigates the role of Rabconnectin3 in auditory function using zebrafish as a genetic model for congenital deafness. Rabconnectin3 was identified as essential for synaptic vesicle acidification and proper hair cell function, critical for hearing and balance. Experimental approaches included developing a novel hearing assay, cloning and characterizing rabconnectin3 mutants, and analyzing its tissue and subcellular distribution. Findings reveal Rabconnectin3’s contribution to Vacuolar-type Proton Pump stability and vesicle lumen acidification, highlighting its previously unknown role in auditory physiology. These results advance understanding of genetic mechanisms underlying hearing loss.
000000897 540__ $$fCC BY
000000897 542__ $$fIn copyright - single owner
000000897 650__ $$aHearing$$019916
000000897 650__ $$aVacuolar Proton-Translocating ATPases$$033184
000000897 650__ $$aCloning, Molecular$$016801
000000897 650__ $$aDeafness$$017398
000000897 650__ $$aHearing Loss$$034564
000000897 650__ $$aVestibulocochlear Physiological Phenomena$$013399
000000897 650__ $$aZebrafish$$028076
000000897 650__ $$aHair Cells, Auditory$$019810
000000897 650__ $$aSignal Transduction$$028380
000000897 6531_ $$acellular signal transduction
000000897 6531_ $$aadaptor proteins
000000897 691__ $$aSchool of Medicine$$041369
000000897 692__ $$aVollum Institute$$041509
000000897 7001_ $$aEinhorn, Zev$$uOregon Health and Science University$$041354
000000897 7201_ $$aNicolson, Teresa$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000897 8564_ $$987cc67b7-a05b-4ecd-9926-571ba435a616$$s4094339$$uhttps://digitalcollections.ohsu.edu/record/897/files/900_etd.pdf$$ePublic$$28573f44953c1923ab892a13c152c7aa1$$31
000000897 905__ $$a/rest/prod/ms/35/t8/65/ms35t865t
000000897 909CO $$ooai:digitalcollections.ohsu.edu:897$$pstudent-work
000000897 980__ $$aTheses and Dissertations