TY  - THES
AB  - Parasitic protozoa, which are auxotrophic for purines, have evolved a unique metabolic pathway, the purine salvage pathway, to meet their requirements for purines. Since they are unable to synthesize their purines, they must salvage these essential nutrients from their hosts. Numerous enzymes are involved in allowing the parasitic protozoa to obtain the purines it needs from its host, the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). Appears to be a key enzyme in purine salvage Salvage used by these parasites. This thesis examines the role of the active site residue lysine 157 within the HGPRT of Leishmania donovani.
AD  - Oregon Health and Science University
AU  - Barton, Gregory
DA  - 2004-06-01
DO  - 10.6083/M4RF5S2F
DO  - DOI
ED  - Ullman, Buddy
ED  - Advisor
ID  - 8977
KW  - Hypoxanthine Phosphoribosyltransferase
KW  - Leishmania donovani
KW  - Purines
L1  - https://digitalcollections.ohsu.edu/record/8977/files/2004.barton.gregory.pdf
L2  - https://digitalcollections.ohsu.edu/record/8977/files/2004.barton.gregory.pdf
L4  - https://digitalcollections.ohsu.edu/record/8977/files/2004.barton.gregory.pdf
LK  - https://digitalcollections.ohsu.edu/record/8977/files/2004.barton.gregory.pdf
N2  - Parasitic protozoa, which are auxotrophic for purines, have evolved a unique metabolic pathway, the purine salvage pathway, to meet their requirements for purines. Since they are unable to synthesize their purines, they must salvage these essential nutrients from their hosts. Numerous enzymes are involved in allowing the parasitic protozoa to obtain the purines it needs from its host, the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). Appears to be a key enzyme in purine salvage Salvage used by these parasites. This thesis examines the role of the active site residue lysine 157 within the HGPRT of Leishmania donovani.
PB  - Oregon Health and Science University
PY  - 2004-06-01
T1  - Site directed mutagenesis of residue lysine 157 of the hypoxanthine-guanine phosphoribosyltransferase gene from Leishmania donovani and kinetic analysis and comparison of site directed mutants with the recombinant wild type enzyme
TI  - Site directed mutagenesis of residue lysine 157 of the hypoxanthine-guanine phosphoribosyltransferase gene from Leishmania donovani and kinetic analysis and comparison of site directed mutants with the recombinant wild type enzyme
UR  - https://digitalcollections.ohsu.edu/record/8977/files/2004.barton.gregory.pdf
Y1  - 2004-06-01
ER  -