000000903 001__ 903 000000903 005__ 20250515154356.0 000000903 0247_ $$2DOI$$a10.6083/M4XK8CJT 000000903 037__ $$aETD 000000903 245__ $$aCross-sectional analysis of candidate genes for cognitive impairment in the osteoporotic fractures in men study 000000903 260__ $$bOregon Health and Science University 000000903 269__ $$a2013-02-01 000000903 336__ $$aThesis 000000903 502__ $$bM.P.H. 000000903 502__ $$gPublic Health 000000903 520__ $$aCognitive deficits are an early feature of Alzheimer’s disease (AD) and vascular dementia (VD). Brain white matter hyperintensities (WMH), identified with MRI, are thought to represent cerebrovascular pathology and are a risk factor for cognitive decline. Six genes in the 17q25 region were recently identified as being associated with WMH burden. I aimed to test if these genes are associated with cognitive dysfunction in elderly men. 000000903 542__ $$aIn copyright - single owner 000000903 650__ $$aMen$$022015 000000903 650__ $$aAged$$014351 000000903 650__ $$aLeukoencephalopathies$$038714 000000903 650__ $$aGenetic Association Studies$$038681 000000903 650__ $$aExecutive Function$$038584 000000903 650__ $$aDementia, Vascular$$028173 000000903 650__ $$aAlzheimer Disease$$014513 000000903 650__ $$aGenetic Research$$034736 000000903 6531_ $$abrain degeneration 000000903 691__ $$aSchool of Medicine$$041369 000000903 692__ $$aDepartment of Public Health and Preventive Medicine$$041444 000000903 7001_ $$aGribbin, Jenna$$uOregon Health and Science University$$041354 000000903 8564_ $$9a378fe52-1408-4b44-9879-aba9676cb393$$s3626759$$uhttps://digitalcollections.ohsu.edu/record/903/files/906_etd.pdf$$ePublic$$2eadb494f15c9616e8cbaf7eb5f809708$$31 000000903 905__ $$a/rest/prod/cr/56/n1/04/cr56n104t 000000903 909CO $$ooai:digitalcollections.ohsu.edu:903$$pstudent-work 000000903 980__ $$aTheses and Dissertations