@article{ETD,
      school = {Ph.D.},
      author = {Kim, Hyun J.},
      url = {http://digitalcollections.ohsu.edu/record/9098},
      title = {Discovery of early cancer signatures in circulating RNA  and extracellular vesicles},
      publisher = {Oregon Health and Science University},
      abstract = {This thesis work highlights development and applications  for both circulating extracellular vesicles (EV) and  cell-free RNA (cf-RNA) toward liquid biopsy based early  cancer detection methodologies. Effective detection and  monitoring for signatures of oncological disease in a  noninvasive manner are urgently needed to reduce the  morbidity and mortality caused by cancer. Circulating EVs  and cf-RNA are intensely sought after biomarkers in liquid  biopsy. Their roles in cell-to-cell communication, ability  to reflect phenotypic changes from cells, and tissues of  origin are becoming better understood. Despite this,  current literatures present key challenges which limit the  promise of liquid biopsy based early cancer detection: i)  there is a lack of standardized blood processing for  multi-omics which minimizes ex-vivo processing artefacts  via discerning true in-vivo signatures from ex-vivo  artefacts; ii) daily fluctuations and the influence of meal  consumption on EV and cf-RNA levels are not clear; iii) a  comprehensive study of cf-RNA for cancer detection, pan  cancer discernment, and high risk group identification has  not been conducted; and iv) the selective packaging of  cf-RNA carriers and its association with cancer are  unknown.},
      number = {ETD},
      doi = {https://doi.org/10.6083/xs55mc819},
      recid = {9098},
      address = {2021},
}