TY  - GEN
N2  - This dissertation explores the capacity of direct chemical modification of existing aptamer structures for the discovery of novel functional applications using a closely related family of fluorescent aptamers as a model system. Further, this dissertation explores the merits of reusing validated structural motifs for the accelerated discovery of novel aptamer utility. This work additionally raises broad questions about the influence of sequence identity and proximity of structure in G-quadruplex-cation interactions, and its relationship to G-Quadruplex behavior with implications for rational tuning, and the merits of structural recycling and functional reprogramming of aptamers as a conceptual alternative to de novo aptamer generation.
DO  - 10.6083/3197xm90m
DO  - DOI
AB  - This dissertation explores the capacity of direct chemical modification of existing aptamer structures for the discovery of novel functional applications using a closely related family of fluorescent aptamers as a model system. Further, this dissertation explores the merits of reusing validated structural motifs for the accelerated discovery of novel aptamer utility. This work additionally raises broad questions about the influence of sequence identity and proximity of structure in G-quadruplex-cation interactions, and its relationship to G-Quadruplex behavior with implications for rational tuning, and the merits of structural recycling and functional reprogramming of aptamers as a conceptual alternative to de novo aptamer generation.
T1  - Structural recycling  of model fluorescent  aptamers
DA  - 2021
AU  - Savage, Jonathan C.
L1  - https://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9112
L4  - https://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
KW  - Potassium
KW  - Nucleotides
KW  - SELEX Aptamer Technique
KW  - fluorescence microscopy
KW  - biosensors
TI  - Structural recycling  of model fluorescent  aptamers
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
ER  -