000009112 001__ 9112
000009112 005__ 20240124114317.0
000009112 0247_ $$2DOI$$a10.6083/3197xm90m
000009112 037__ $$aETD
000009112 245__ $$aStructural recycling  of model fluorescent  aptamers
000009112 260__ $$bOregon Health and Science University
000009112 269__ $$a2021
000009112 336__ $$aDissertation
000009112 502__ $$bPh.D.
000009112 520__ $$aThis dissertation explores the capacity of direct chemical modification of existing aptamer structures for the discovery of novel functional applications using a closely related family of fluorescent aptamers as a model system. Further, this dissertation explores the merits of reusing validated structural motifs for the accelerated discovery of novel aptamer utility. This work additionally raises broad questions about the influence of sequence identity and proximity of structure in G-quadruplex-cation interactions, and its relationship to G-Quadruplex behavior with implications for rational tuning, and the merits of structural recycling and functional reprogramming of aptamers as a conceptual alternative to de novo aptamer generation.
000009112 542__ $$fIn copyright - single owner
000009112 650__ $$aPotassium$$024467
000009112 650__ $$aNucleotides$$023064
000009112 650__ $$aSELEX Aptamer Technique$$037113
000009112 6531_ $$afluorescence microscopy
000009112 6531_ $$abiosensors
000009112 691__ $$aSchool of Medicine$$041369
000009112 7001_ $$aSavage, Jonathan C.
000009112 8564_ $$90ef05234-efe5-4808-aaa4-4f4aecf54991$$s19338230$$uhttps://digitalcollections.ohsu.edu/record/9112/files/Savage.Jonathan.2021.pdf
000009112 905__ $$a/rest/prod/31/97/xm/90/3197xm90m
000009112 909CO $$ooai:digitalcollections.ohsu.edu:9112$$pstudent-work
000009112 980__ $$aTheses and Dissertations