000009115 001__ 9115 000009115 005__ 20231129124948.0 000009115 0247_ $$2DOI$$a10.6083/dj52w5544 000009115 037__ $$aETD 000009115 245__ $$aThe liver is a dynamic organ shaped by reproduction with implications for young women's breast cancer 000009115 260__ $$bOregon Health and Science University 000009115 269__ $$a2021 000009115 336__ $$aDissertation 000009115 502__ $$bPh.D. 000009115 520__ $$aWomen diagnosed with breast cancer within 10 years of a completed pregnancy are 2~3x more likely to develop liver metastases than never-pregnant (nulliparous) patients, even after controlling for prognostic variables. This finding suggests a unique biology in the postpartum liver, a putative pre-metastatic niche, which makes postpartum patients more susceptible to liver metastases. 000009115 542__ $$fIn copyright - single owner 000009115 650__ $$aRodentia$$025590 000009115 650__ $$aLiver$$021580 000009115 650__ $$aHumans$$020376 000009115 650__ $$aPregnancy$$024523 000009115 650__ $$aBreast Neoplasms$$015809 000009115 6531_ $$ametastatic 000009115 691__ $$aSchool of Medicine$$041369 000009115 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399 000009115 7001_ $$aBartlett, Alexandra Q. 000009115 8564_ $$9c656fdc7-9475-4c14-9df4-9ba7356f0c16$$s8216173$$uhttps://digitalcollections.ohsu.edu/record/9115/files/Bartlett.Alex.2021.pdf 000009115 905__ $$a/rest/prod/dj/52/w5/54/dj52w5544 000009115 909CO $$ooai:digitalcollections.ohsu.edu:9115$$pstudent-work 000009115 980__ $$aTheses and Dissertations