@article{ETD,
      school = {Ph.D.},
      author = {Huang, Samuel J.},
      url = {http://digitalcollections.ohsu.edu/record/9136},
      title = {Transcription-dependent directed evolution of the  adeno-associated virus capsid},
      publisher = {Oregon Health and Science University},
      abstract = {This dissertation describes the development of the TRADE  system for directed evolution of the AAV capsid, its  successful application to identify the HN1 variant, a novel  AAV capsid with enhanced neuronal transduction efficiency  and specificity following intravenous vector administration  in both rodents and rhesus macaques. This work establishes  a novel technology with the potential to facilitate the  rapid development of customized AAV vectors targeting cell  types of choice and has the potential to significantly  impact a wide variety of problems in basic science and  medicine where lack of an efficient vector for targeting a  critical cell type poses a significant barrier. Thus, TRADE  is poised to transform the field of AAV capsid directed  evolution.},
      number = {ETD},
      doi = {https://doi.org/10.6083/cz30pt42j},
      recid = {9136},
      address = {2021},
}