TY  - GEN
AB  - The human heart starts beating at 21 days gestation and does not stop until death. This posits an incessant metabolic demand that must be met despite abrupt changes to cardiac load, nutritional substrates and oxygenation that occurs at birth. Fetal cardiomyocytes rely on lactate and glucose for ATP production, while healthy adult cardiomyocytes utilize mostly fatty acids. This thesis provides new insights into the normal developmental profile of the myocardial fatty acid metabolic pathway in the perinatal period in a precocial species, and the impact of IUGR on this pathway.
AU  - Drake, Rachel R.
DA  - 2021
DO  - 10.6083/9z9030583
DO  - DOI
ID  - 9137
KW  - Metabolism
KW  - Cardiovascular System
KW  - Fatty Acids
KW  - intrauterine growth restriction
L1  - https://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
L2  - https://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
L4  - https://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
N2  - The human heart starts beating at 21 days gestation and does not stop until death. This posits an incessant metabolic demand that must be met despite abrupt changes to cardiac load, nutritional substrates and oxygenation that occurs at birth. Fetal cardiomyocytes rely on lactate and glucose for ATP production, while healthy adult cardiomyocytes utilize mostly fatty acids. This thesis provides new insights into the normal developmental profile of the myocardial fatty acid metabolic pathway in the perinatal period in a precocial species, and the impact of IUGR on this pathway.
PB  - Oregon Health and Science University
PY  - 2021
T1  - Myocardial fatty acid metabolism in normal ovine development and intrauterine growth restriction
TI  - Myocardial fatty acid metabolism in normal ovine development and intrauterine growth restriction
UR  - https://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
Y1  - 2021
ER  -