000009137 001__ 9137
000009137 005__ 20240124114318.0
000009137 0247_ $$2DOI$$a10.6083/9z9030583
000009137 037__ $$aETD
000009137 245__ $$aMyocardial fatty acid metabolism in normal ovine development and intrauterine growth restriction
000009137 260__ $$bOregon Health and Science University
000009137 269__ $$a2021
000009137 336__ $$aDissertation
000009137 502__ $$bPh.D.
000009137 520__ $$aThe human heart starts beating at 21 days gestation and does not stop until death. This posits an incessant metabolic demand that must be met despite abrupt changes to cardiac load, nutritional substrates and oxygenation that occurs at birth. Fetal cardiomyocytes rely on lactate and glucose for ATP production, while healthy adult cardiomyocytes utilize mostly fatty acids. This thesis provides new insights into the normal developmental profile of the myocardial fatty acid metabolic pathway in the perinatal period in a precocial species, and the impact of IUGR on this pathway.
000009137 542__ $$fIn copyright - single owner
000009137 650__ $$aMetabolism$$022101
000009137 650__ $$aCardiovascular System$$016153
000009137 650__ $$aFatty Acids$$018911
000009137 6531_ $$aintrauterine growth restriction
000009137 691__ $$aSchool of Medicine$$041369
000009137 7001_ $$aDrake, Rachel R.
000009137 8564_ $$98bcdc69a-db9a-47fb-9cc0-728e5bc59e32$$s3008237$$uhttps://digitalcollections.ohsu.edu/record/9137/files/Drake.Rachel.2021.pdf
000009137 905__ $$a/rest/prod/9z/90/30/58/9z9030583
000009137 909CO $$ooai:digitalcollections.ohsu.edu:9137$$pstudent-work
000009137 980__ $$aTheses and Dissertations