000009139 001__ 9139
000009139 005__ 20231129124947.0
000009139 0247_ $$2DOI$$a10.6083/44558d85s
000009139 037__ $$aETD
000009139 245__ $$aInvestigations of primate placentation under normal and pathological pregnancy conditions
000009139 260__ $$bOregon Health and Science University
000009139 269__ $$a2021
000009139 336__ $$aDissertation
000009139 502__ $$bPh.D.
000009139 520__ $$aNormal placentation is essential for the health and well-being of both the mother and fetus throughout pregnancy. In humans, defective placental development contributes to pregnancy complications such as preeclampsia, fetal growth restriction, and preterm birth. The etiology of these pregnancy disorders is poorly understood since they are thought to arise during the early stages of development which is difficult to study in humans due to ethical reasons. My studies highlighted the expression of ERVK11q23.3, an ERVK locus present in the human but not the rhesus genome, that is highly expressed in mononuclear trophoblasts and upregulated in human preterm compared to term placental tissue. I also provide evidence that altered placental expression of ERVK11q23.3 influences IFN antiviral response, which may contribute to preterm birth and other pregnancy complications in humans.
000009139 542__ $$fIn copyright - single owner
000009139 650__ $$aPlacentation$$024219
000009139 650__ $$aPre-Eclampsia$$024503
000009139 650__ $$aEndogenous Retroviruses$$032106
000009139 650__ $$aPregnancy$$024523
000009139 650__ $$aMacaca mulatta$$021724
000009139 650__ $$aTrophoblasts$$027422
000009139 691__ $$aSchool of Medicine$$041369
000009139 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000009139 7001_ $$aRosenkrantz, Jimi L.
000009139 8564_ $$9a443ddfe-ab95-4a3a-8422-5176e29af5b0$$s7248893$$uhttps://digitalcollections.ohsu.edu/record/9139/files/Rosenkrantz.Jimi.2021.pdf
000009139 905__ $$a/rest/prod/44/55/8d/85/44558d85s
000009139 909CO $$ooai:digitalcollections.ohsu.edu:9139$$pstudent-work
000009139 980__ $$aTheses and Dissertations