000000917 001__ 917
000000917 005__ 20251205093205.0
000000917 0247_ $$2DOI$$a10.6083/M4445JHP
000000917 037__ $$aETD
000000917 245__ $$aBone health and quality of life in children with Duchenne muscular dystrophy
000000917 260__ $$bOregon Health and Science University
000000917 269__ $$a2013
000000917 336__ $$aThesis
000000917 502__ $$bM.P.H.
000000917 520__ $$aDuchenne muscular dystrophy (DMD), affecting 1 in 3,500 male births, is associated with reduced life expectancy and increased fracture risk, yet contributing factors and their impact on quality of life remain unclear. This study examined fracture prevalence and its relationship to health-related quality of life in 57 children with DMD at Shriners Hospital, Portland. Surveys using PedsQL and chart reviews were analyzed with multivariable regression. Fractures occurred in 30% of participants and were linked to lower functional quality of life scores (p=0.05) and marginally lower emotional scores (p=0.06). Potential fracture risk factors included ambulatory status and recent functional decline. Findings suggest fractures negatively affect quality of life, highlighting the need for preventive strategies targeting disuse-related bone loss and further research on DMD’s impact on bone remodeling.
000000917 540__ $$fCC BY
000000917 542__ $$fIn copyright - single owner
000000917 650__ $$aQuality of Life$$025032
000000917 650__ $$aOsteoporosis$$023359
000000917 650__ $$aRisk Factors$$025522
000000917 650__ $$aChild$$016462
000000917 650__ $$aMale$$021762
000000917 650__ $$aMuscular Dystrophy, Duchenne$$032376
000000917 650__ $$aFractures, Bone$$036511
000000917 691__ $$aSchool of Medicine$$041369
000000917 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000000917 7001_ $$aRiss, Valerie$$uOregon Health and Science University$$041354
000000917 7201_ $$aNielson, Carrie$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000917 8564_ $$93685491f-0684-43e2-85cb-5b4afbf36714$$s1392456$$uhttps://digitalcollections.ohsu.edu/record/917/files/920_etd.pdf$$ePublic$$223f7719ae9b1fc5fb01011c7eb4dae65$$31
000000917 905__ $$a/rest/prod/gh/93/gz/56/gh93gz56x
000000917 909CO $$ooai:digitalcollections.ohsu.edu:917$$pstudent-work
000000917 980__ $$aTheses and Dissertations