TY  - GEN
N2  - Uveal melanoma (UM) is a rare but aggressive disease, with >50% of tumors propagating metastatic disease spread - associated with nearly uniform fatality. Despite significant advances in molecular prognostic tests for identifying patients at risk for developing metastatic disease, the biological process underlying development of metastasis in UM remains poorly understood. Further characterization of neoplastic hybrid cells within UM will assist in the identification of targetable pathways that may mediate metastatic disease development. In addition, this work provides a platform for identifying and evaluating neoplastic hybrid cells that can be applied to existing scRNA-seq datasets of other cancer types.
DO  - 10.6083/br86b4109
DO  - DOI
AB  - Uveal melanoma (UM) is a rare but aggressive disease, with >50% of tumors propagating metastatic disease spread - associated with nearly uniform fatality. Despite significant advances in molecular prognostic tests for identifying patients at risk for developing metastatic disease, the biological process underlying development of metastasis in UM remains poorly understood. Further characterization of neoplastic hybrid cells within UM will assist in the identification of targetable pathways that may mediate metastatic disease development. In addition, this work provides a platform for identifying and evaluating neoplastic hybrid cells that can be applied to existing scRNA-seq datasets of other cancer types.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Identification and characterization of neoplastic hybrid cells in uveal melanoma
DA  - 2021
AU  - Anderson, Ashley N.
AU  - Sengupta, Sidharth
AU  - Gibbs, Summer
AU  - Wong, Melissa
L1  - https://digitalcollections.ohsu.edu/record/9185/files/Anderson-Ashley-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9185
L4  - https://digitalcollections.ohsu.edu/record/9185/files/Anderson-Ashley-OHSU-ResearchWeek-2021.pdf
KW  - Neoplasm Metastasis
KW  - Single-Cell Analysis
KW  - Sequence Analysis, RNA
KW  - Hybrid Cells
KW  - intraocular melanoma
KW  - cancer biology
KW  - single cell RNA sequencing
KW  - uveal melanoma
TI  - Identification and characterization of neoplastic hybrid cells in uveal melanoma
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9185/files/Anderson-Ashley-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9185/files/Anderson-Ashley-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9185/files/Anderson-Ashley-OHSU-ResearchWeek-2021.pdf
ER  -