000009186 001__ 9186
000009186 005__ 20240124114319.0
000009186 0247_ $$2DOI$$a10.6083/3x816n482
000009186 037__ $$aETD
000009186 245__ $$aLipocalin 2 as a pathologic mediator of cancer cachexia and neurocognitive decline
000009186 260__ $$bOregon Health and Science University
000009186 269__ $$a2021
000009186 336__ $$aDissertation
000009186 502__ $$bPh.D.
000009186 520__ $$aIllness behaviors, metabolic disturbances, and cognitive injury are common in cancer patients and frequently lead to wasting or cachexia. This devastating state of malnutrition is brought about by a synergistic combination of decreased appetite and increase in metabolism of fat and lean body mass. The severity of cachexia is often the primary determining factor in both quality of life and ultimate survival. There are currently no effective treatments for cachexia, and its mechanisms are poorly understood. Our lab has previously elucidated the actions of inflammatory cytokines, including IL-1β and TNF-α, on hypothalamic neurons and their roles in driving cachexia symptoms. However, chronic administration of these cytokines results in desensitization and loss of cachexia symptoms, demonstrating canonical inflammatory cytokines alone are insufficient for sustaining cachexia. These observations and more demonstrate that the molecular pathways responsible for driving chronic central nervous system (CNS) derangement and cachexia symptoms remain unknown.
000009186 542__ $$fIn copyright - single owner
000009186 650__ $$aPancreatic Neoplasms$$023517
000009186 650__ $$aCachexia$$015945
000009186 650__ $$aLipocalin-2$$011679
000009186 650__ $$aHead and Neck Neoplasms$$019866
000009186 6531_ $$acognitive decline
000009186 6531_ $$acancer
000009186 691__ $$aSchool of Medicine$$041369
000009186 7001_ $$aOlson, Brennan G.
000009186 8564_ $$9df4546fa-ca41-4525-a50b-08e1672b23c1$$s8422182$$uhttps://digitalcollections.ohsu.edu/record/9186/files/Olson.Brennan.2021.pdf
000009186 905__ $$a/rest/prod/3x/81/6n/48/3x816n482
000009186 909CO $$ooai:digitalcollections.ohsu.edu:9186$$pstudent-work
000009186 980__ $$aTheses and Dissertations