TY - GEN AB - As a part of the Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) precision medicine cancer trial, serial biopsies from cancer patients are collected and analyzed to inform treatment and advance the understanding of metastatic cancer. As of now, manual segmentation is a major time limiting factor in EM image analysis for cancer tissue. In order to combat this, there are projects underway to develop machine learning algorithms to automate segmentation. Automation will hopefully allow electron microscope analysis to be a new and informative avenue for cancer research. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Bueno, Cecilia AU - Riesterer, Jessica AU - Smith, Hannah AU - Machireddy, Archana AU - Stempinski, Erin AU - Loftis, Kevin AU - Stoltz, Kevin AU - Gray, Joe DA - 2021 DO - 10.6083/m039k5667 DO - DOI ID - 9197 KW - Tumor Microenvironment KW - Image Processing, Computer-Assisted KW - Microscopy, Electron KW - Cell Communication KW - cancer KW - FIB-SEM KW - neoplasms L1 - https://digitalcollections.ohsu.edu/record/9197/files/Bueno-Cecilia-OHSU-ResearchWeek-2021.pdf L2 - https://digitalcollections.ohsu.edu/record/9197/files/Bueno-Cecilia-OHSU-ResearchWeek-2021.pdf L4 - https://digitalcollections.ohsu.edu/record/9197/files/Bueno-Cecilia-OHSU-ResearchWeek-2021.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/9197/files/Bueno-Cecilia-OHSU-ResearchWeek-2021.pdf N2 - As a part of the Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) precision medicine cancer trial, serial biopsies from cancer patients are collected and analyzed to inform treatment and advance the understanding of metastatic cancer. As of now, manual segmentation is a major time limiting factor in EM image analysis for cancer tissue. In order to combat this, there are projects underway to develop machine learning algorithms to automate segmentation. Automation will hopefully allow electron microscope analysis to be a new and informative avenue for cancer research. PB - Oregon Health and Science University PY - 2021 T1 - Taking a closer look: imaging tumor microenvironments with 3D FIB-SEM reveals complex cellular interactions TI - Taking a closer look: imaging tumor microenvironments with 3D FIB-SEM reveals complex cellular interactions UR - https://digitalcollections.ohsu.edu/record/9197/files/Bueno-Cecilia-OHSU-ResearchWeek-2021.pdf Y1 - 2021 ER -