TY  - GEN
N2  - Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic.
DO  - 10.6083/f4752h44n
DO  - DOI
AB  - Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Androgen receptor regulation of T cell immune responses
DA  - 2021
AU  - Hawkins, Reed
AU  - Sehrawat, Archana
AU  - Polesso, Fanny
AU  - Moran, Amy
L1  - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2021
ID  - 9215
L4  - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
KW  - Autoimmunity
KW  - Immunity
KW  - Androgens
KW  - T-Lymphocytes
KW  - t cell immunity
KW  - androgen receptor
KW  - lymphocytes
TI  - Androgen receptor regulation of T cell immune responses
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
ER  -