TY - GEN AB - Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Hawkins, Reed AU - Sehrawat, Archana AU - Polesso, Fanny AU - Moran, Amy DA - 2021 DO - 10.6083/f4752h44n DO - DOI ID - 9215 KW - Autoimmunity KW - Immunity KW - Androgens KW - T-Lymphocytes KW - t cell immunity KW - androgen receptor KW - lymphocytes L1 - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf L2 - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf L4 - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf N2 - Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic. PB - Oregon Health and Science University PY - 2021 T1 - Androgen receptor regulation of T cell immune responses TI - Androgen receptor regulation of T cell immune responses UR - https://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf Y1 - 2021 ER -