000009215 001__ 9215
000009215 005__ 20240327154927.0
000009215 0247_ $$2DOI$$a10.6083/f4752h44n
000009215 037__ $$aIR
000009215 041__ $$aeng
000009215 245__ $$aAndrogen receptor regulation of T cell immune responses
000009215 260__ $$bOregon Health and Science University
000009215 269__ $$a2021
000009215 336__ $$aAbstract
000009215 520__ $$aSex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to infections and malignancies, and females more susceptible to autoimmune diseases. While many factors underlie such differences, sex differences in T lymphocytes differentiation and function likely lead to disparate adaptive immune responses and disease control. Indeed, sex hormones, including androgens, are strong regulators of gene expression, and have been implicated as drivers of immunity and regulators of T cell differentiation. Therefore, it is clear that androgens play a role in the regulation of T cell function and differentiation, but the mechanisms of such control remain unknown, including whether such regulation is cell-intrinsic.
000009215 540__ $$fCC BY
000009215 542__ $$fIn copyright - joint owners
000009215 650__ $$aAutoimmunity$$028491
000009215 650__ $$aImmunity$$020668
000009215 650__ $$aAndrogens$$014685
000009215 650__ $$aT-Lymphocytes$$026731
000009215 6531_ $$at cell immunity
000009215 6531_ $$aandrogen receptor
000009215 6531_ $$alymphocytes
000009215 7001_ $$aHawkins, Reed$$uOregon Health and Science University$$041354
000009215 7001_ $$aSehrawat, Archana$$uOregon Health and Science University$$041354
000009215 7001_ $$aPolesso, Fanny$$uOregon Health and Science University$$041354
000009215 7001_ $$aMoran, Amy$$uOregon Health and Science University$$041354
000009215 711__ $$aResearch Week$$uOregon Health and Science University$$d2021
000009215 8564_ $$9ccc88edd-d83e-4682-a2bf-27174a654739$$s62833$$uhttps://digitalcollections.ohsu.edu/record/9215/files/Hawkins-Reed-OHSU-ResearchWeek-2021.pdf
000009215 905__ $$a/rest/prod/f4/75/2h/44/f4752h44n
000009215 980__ $$aResearch Week