TY  - GEN
N2  - Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the GI tract. The second most common type of GIST is driven by oncogenic mutations in PDGFRA, of which there are 50+ different kinase domain mutations reported. 82% of these occur in the kinase activation loop (AL), with the majority being a single point mutation, D842V. PDGFRA-D842V is notoriously resistant to conventional tyrosine kinase inhibitors approved for GIST, including imatinib. However, it isn't known how GIST with other PDGFRA AL mutations, which include numerous complex indels, would clinically respond to imatinib.
DO  - 10.6083/8w32r639w
DO  - DOI
AB  - Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the GI tract. The second most common type of GIST is driven by oncogenic mutations in PDGFRA, of which there are 50+ different kinase domain mutations reported. 82% of these occur in the kinase activation loop (AL), with the majority being a single point mutation, D842V. PDGFRA-D842V is notoriously resistant to conventional tyrosine kinase inhibitors approved for GIST, including imatinib. However, it isn't known how GIST with other PDGFRA AL mutations, which include numerous complex indels, would clinically respond to imatinib.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Primary Imatinib resistance in PDGFRA-mutant GIST
DA  - 2021
AU  - Khosroyani, Homma M.
AU  - Klug, Lillian
AU  - Heinrich, Michael
L1  - https://digitalcollections.ohsu.edu/record/9219/files/Khosroyani-Homma-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9219
L4  - https://digitalcollections.ohsu.edu/record/9219/files/Khosroyani-Homma-OHSU-ResearchWeek-2021.pdf
KW  - Sarcoma
KW  - Imatinib Mesylate
KW  - Protein Kinase Inhibitors
KW  - Drug Resistance
KW  - Gastrointestinal Stromal Tumors
KW  - cancer
KW  - neoplasms
TI  - Primary Imatinib resistance in PDGFRA-mutant GIST
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9219/files/Khosroyani-Homma-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9219/files/Khosroyani-Homma-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9219/files/Khosroyani-Homma-OHSU-ResearchWeek-2021.pdf
ER  -