@article{IR,
      author = {Luong, Nina and Pomaville, Matthew and Wright, Kevin},
      url = {http://digitalcollections.ohsu.edu/record/9227},
      title = {Characterizing DRG axon phenotypes in a novel Lfng mutant},
      publisher = {Oregon Health and Science University},
      abstract = {During embryonic development, structures such as the  vertebral column, ribs, trunk muscles, and meninges arise  from blocks of mesoderm called somites that surround the  neural tube, a precursor to the central nervous system.  Precise regulation of the Notch signaling pathway is  required for establishing somite boundaries and patterning.  Mutations in Lunatic Fringe (Lfng), a fucose-specific beta  1,3-N acetyltransferase that regulates Notch signaling,  results in abnormal spacing of the somites and their  derivatives, resulting in stereotypical skeletal  malformations and spondylocostal dysostosis, a recessive  disorder that results in malformations of the vertebral  column and ribs resulting in shortened trunks and  respiratory difficulties. In the present study, we sought  to understand how DRG axon branching is affected throughout  development and whether specific subtypes of DRG neurons  are affected in LfngC20R mutants. We also examined whether  the axon guidance phenotype is DRG-autonomous or due to  alterations in the surrounding environment.},
      number = {IR},
      doi = {https://doi.org/10.6083/bk128b60s},
      recid = {9227},
      address = {2021},
}