TY  - GEN
N2  - During embryonic development, structures such as the vertebral column, ribs, trunk muscles, and meninges arise from blocks of mesoderm called somites that surround the neural tube, a precursor to the central nervous system. Precise regulation of the Notch signaling pathway is required for establishing somite boundaries and patterning. Mutations in Lunatic Fringe (Lfng), a fucose-specific beta 1,3-N acetyltransferase that regulates Notch signaling, results in abnormal spacing of the somites and their derivatives, resulting in stereotypical skeletal malformations and spondylocostal dysostosis, a recessive disorder that results in malformations of the vertebral column and ribs resulting in shortened trunks and respiratory difficulties. In the present study, we sought to understand how DRG axon branching is affected throughout development and whether specific subtypes of DRG neurons are affected in LfngC20R mutants. We also examined whether the axon guidance phenotype is DRG-autonomous or due to alterations in the surrounding environment.
DO  - 10.6083/bk128b60s
DO  - DOI
AB  - During embryonic development, structures such as the vertebral column, ribs, trunk muscles, and meninges arise from blocks of mesoderm called somites that surround the neural tube, a precursor to the central nervous system. Precise regulation of the Notch signaling pathway is required for establishing somite boundaries and patterning. Mutations in Lunatic Fringe (Lfng), a fucose-specific beta 1,3-N acetyltransferase that regulates Notch signaling, results in abnormal spacing of the somites and their derivatives, resulting in stereotypical skeletal malformations and spondylocostal dysostosis, a recessive disorder that results in malformations of the vertebral column and ribs resulting in shortened trunks and respiratory difficulties. In the present study, we sought to understand how DRG axon branching is affected throughout development and whether specific subtypes of DRG neurons are affected in LfngC20R mutants. We also examined whether the axon guidance phenotype is DRG-autonomous or due to alterations in the surrounding environment.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Characterizing DRG axon phenotypes in a novel Lfng mutant
DA  - 2021
AU  - Luong, Nina
AU  - Pomaville, Matthew
AU  - Wright, Kevin
L1  - https://digitalcollections.ohsu.edu/record/9227/files/Luong-Nina-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2021
ID  - 9227
L4  - https://digitalcollections.ohsu.edu/record/9227/files/Luong-Nina-OHSU-ResearchWeek-2021.pdf
KW  - Glycosyltransferases
KW  - Somites
KW  - Embryonic Development
KW  - Spinal Cord
KW  - Mesoderm
KW  - Receptors, Notch
KW  - embryo
KW  - lunatic fringe
TI  - Characterizing DRG axon phenotypes in a novel Lfng mutant
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9227/files/Luong-Nina-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9227/files/Luong-Nina-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9227/files/Luong-Nina-OHSU-ResearchWeek-2021.pdf
ER  -