TY  - GEN
N2  - Cells in vivo are continuously exposed to a range of small messenger proteins (microenvironmental ligands). Microenvironmental ligands bind to cell-surface receptors and trigger protein cascades that impact many aspects of cell behavior. Aberrations in the ligand signaling network can drive the progression of many different pathologies, including cancer. Our prior research has characterized the molecular and phenotypic changes that occur in MCF10A cells, a mammary epithelial cell line, treated with a panel of six microenvironmental ligands that target different canonical pathways. Cells exposed to the perturbagens were assayed for gross phenotypic, proteomic, RNA expression, and epigenetic changes.
DO  - 10.6083/sx61dn151
DO  - DOI
AB  - Cells in vivo are continuously exposed to a range of small messenger proteins (microenvironmental ligands). Microenvironmental ligands bind to cell-surface receptors and trigger protein cascades that impact many aspects of cell behavior. Aberrations in the ligand signaling network can drive the progression of many different pathologies, including cancer. Our prior research has characterized the molecular and phenotypic changes that occur in MCF10A cells, a mammary epithelial cell line, treated with a panel of six microenvironmental ligands that target different canonical pathways. Cells exposed to the perturbagens were assayed for gross phenotypic, proteomic, RNA expression, and epigenetic changes.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Oncostatin M induces migratory and morphological  changes in mammary epithelial cells
DA  - 2021
AU  - McLean, Ian
AU  - Grosse, Sean
AU  - Heiser, Laura
L1  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2021
ID  - 9232
L4  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
KW  - Cell Movement
KW  - Cell Biology
KW  - Signal Transduction
KW  - Epithelial Cells
KW  - Multiomics
KW  - cell migration
KW  - cancer
KW  - cytokine signaling
TI  - Oncostatin M induces migratory and morphological  changes in mammary epithelial cells
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
ER  -