TY  - GEN
AB  - Cells in vivo are continuously exposed to a range of small messenger proteins (microenvironmental ligands). Microenvironmental ligands bind to cell-surface receptors and trigger protein cascades that impact many aspects of cell behavior. Aberrations in the ligand signaling network can drive the progression of many different pathologies, including cancer. Our prior research has characterized the molecular and phenotypic changes that occur in MCF10A cells, a mammary epithelial cell line, treated with a panel of six microenvironmental ligands that target different canonical pathways. Cells exposed to the perturbagens were assayed for gross phenotypic, proteomic, RNA expression, and epigenetic changes.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - McLean, Ian
AU  - Grosse, Sean
AU  - Heiser, Laura
DA  - 2021
DO  - 10.6083/sx61dn151
DO  - DOI
ID  - 9232
KW  - Cell Movement
KW  - Cell Biology
KW  - Signal Transduction
KW  - Epithelial Cells
KW  - Multiomics
KW  - cell migration
KW  - cancer
KW  - cytokine signaling
L1  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
L2  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
L4  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
N2  - Cells in vivo are continuously exposed to a range of small messenger proteins (microenvironmental ligands). Microenvironmental ligands bind to cell-surface receptors and trigger protein cascades that impact many aspects of cell behavior. Aberrations in the ligand signaling network can drive the progression of many different pathologies, including cancer. Our prior research has characterized the molecular and phenotypic changes that occur in MCF10A cells, a mammary epithelial cell line, treated with a panel of six microenvironmental ligands that target different canonical pathways. Cells exposed to the perturbagens were assayed for gross phenotypic, proteomic, RNA expression, and epigenetic changes.
PB  - Oregon Health and Science University
PY  - 2021
T1  - Oncostatin M induces migratory and morphological  changes in mammary epithelial cells
TI  - Oncostatin M induces migratory and morphological  changes in mammary epithelial cells
UR  - https://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
Y1  - 2021
ER  -