000009232 001__ 9232
000009232 005__ 20240412161626.0
000009232 0247_ $$2DOI$$a10.6083/sx61dn151
000009232 037__ $$aIR
000009232 041__ $$aeng
000009232 245__ $$aOncostatin M induces migratory and morphological  changes in mammary epithelial cells
000009232 260__ $$bOregon Health and Science University
000009232 269__ $$a2021
000009232 336__ $$aAbstract
000009232 520__ $$aCells in vivo are continuously exposed to a range of small messenger proteins (microenvironmental ligands). Microenvironmental ligands bind to cell-surface receptors and trigger protein cascades that impact many aspects of cell behavior. Aberrations in the ligand signaling network can drive the progression of many different pathologies, including cancer. Our prior research has characterized the molecular and phenotypic changes that occur in MCF10A cells, a mammary epithelial cell line, treated with a panel of six microenvironmental ligands that target different canonical pathways. Cells exposed to the perturbagens were assayed for gross phenotypic, proteomic, RNA expression, and epigenetic changes.
000009232 540__ $$fCC BY
000009232 542__ $$fIn copyright - joint owners
000009232 650__ $$aCell Movement$$016289
000009232 650__ $$aCell Biology$$017350
000009232 650__ $$aSignal Transduction$$028380
000009232 650__ $$aEpithelial Cells$$018550
000009232 650__ $$aMultiomics$$014089
000009232 6531_ $$acell migration
000009232 6531_ $$acancer
000009232 6531_ $$acytokine signaling
000009232 692__ $$aOHSU Center for Spatial Systems Biomedicine$$041486
000009232 7001_ $$aMcLean, Ian$$uOregon Health and Science University$$041354
000009232 7001_ $$aGrosse, Sean$$uOregon Health and Science University$$041354
000009232 7001_ $$aHeiser, Laura$$uOregon Health and Science University$$041354
000009232 711__ $$aResearch Week$$uOregon Health and Science University$$d2021
000009232 8564_ $$9b60412d8-c902-4d45-ba1d-774bd5c5eaf9$$s51447$$uhttps://digitalcollections.ohsu.edu/record/9232/files/McLean-Ian-OHSU-ResearchWeek-2021.pdf
000009232 905__ $$a/rest/prod/sx/61/dn/15/sx61dn151
000009232 980__ $$aResearch Week