TY - GEN AB - Extracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Palumbo, Michelle C. AU - Shi, Xiao AU - Janowsky, Aaron DA - 2021 DO - 10.6083/1c18dg484 DO - DOI ID - 9240 KW - Schizophrenia KW - Extracellular Vesicles KW - MicroRNAs KW - Mental Disorders KW - Extracellular Vesicles L1 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf L2 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf L4 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf LK - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf N2 - Extracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain. PB - Oregon Health and Science University PY - 2021 T1 - Development of microRNA encapsulated extracellular vesicles for in vivo treatment TI - Development of microRNA encapsulated extracellular vesicles for in vivo treatment UR - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf Y1 - 2021 ER -