TY - GEN N2 - Extracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain. DO - 10.6083/1c18dg484 DO - DOI AB - Extracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University T1 - Development of microRNA encapsulated extracellular vesicles for in vivo treatment DA - 2021 AU - Palumbo, Michelle C. AU - Shi, Xiao AU - Janowsky, Aaron L1 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf PB - Oregon Health and Science University PY - 2021 ID - 9240 L4 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf KW - Schizophrenia KW - Extracellular Vesicles KW - MicroRNAs KW - Mental Disorders KW - Extracellular Vesicles TI - Development of microRNA encapsulated extracellular vesicles for in vivo treatment Y1 - 2021 L2 - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf LK - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf UR - https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf ER -