000009240 001__ 9240 000009240 005__ 20240403115804.0 000009240 0247_ $$2DOI$$a10.6083/1c18dg484 000009240 037__ $$aIR 000009240 245__ $$aDevelopment of microRNA encapsulated extracellular vesicles for in vivo treatment 000009240 260__ $$bOregon Health and Science University 000009240 269__ $$a2021 000009240 336__ $$aAbstract 000009240 520__ $$aExtracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain. 000009240 540__ $$fCC BY 000009240 542__ $$fIn copyright - joint owners 000009240 650__ $$aSchizophrenia$$025757 000009240 650__ $$aExtracellular Vesicles$$011111 000009240 650__ $$aMicroRNAs$$034671 000009240 650__ $$aMental Disorders$$015415 000009240 650__ $$aExtracellular Vesicles$$011111 000009240 7001_ $$aPalumbo, Michelle C.$$uOregon Health and Science University$$041354 000009240 7001_ $$aShi, Xiao$$uOregon Health and Science University$$041354 000009240 7001_ $$aJanowsky, Aaron$$uOregon Health and Science University$$041354 000009240 711__ $$aResearch Week$$uOregon Health and Science University$$d2021 000009240 8564_ $$99b63526f-dab9-40d9-b8e9-165bce4f7856$$s101538$$uhttps://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf 000009240 905__ $$a/rest/prod/1c/18/dg/48/1c18dg484 000009240 980__ $$aResearch Week