Development of microRNA encapsulated extracellular vesicles for in vivo treatment

Schizophrenia Extracellular Vesicles MicroRNAs Mental Disorders 2021

2021

Extracellular vesicles (EVs) transfer critical information for intercellular communication and function by releasing cargo microRNA (miRNA) into target acceptor cells. Upon vesicle fusion, miRNAs regulate gene function and translation and can influence complex genetic networks by inhibiting multiple messenger RNA (mRNA) transcripts. However, it is unknown how EVs transport miRNAs to alter synaptic function in the brain.

Oregon Health and Science University

Abstract

10.6083/1c18dg484

https://digitalcollections.ohsu.edu/record/9240/files/Palumbo-Michelle-OHSU-ResearchWeek-2021.pdf