@article{IR,
      author = {Rios, Samantha and Ingram, Susan and Phillips Richards,  Tamara},
      url = {http://digitalcollections.ohsu.edu/record/9250},
      title = {The role of Lateral Habenula inputs onto Dorsal Raphe  serotonin neurons in regulating methamphetamine induced  aversion},
      publisher = {Oregon Health and Science University},
      abstract = {The CDC reports that 52.9% of people who used MA in the  last year have a MA use disorder. Quantitative trait locus  mapping in selectively bred high and low MA drinking (MADR)  mouse lines identified a single nucleotide polymorphism  (SNP) that accounts for 60% of the genetically determined  differences in MA intake in the MADR lines. This  nonsynonymous substitution mutation within the trace  amine-associated receptor 1 (Taar1) gene alters the protein  amino acid sequence and results in the expression of a  nonfunctional TAAR1 receptor. MA is a full TAAR1 agonist,  and homozygosity for this mutation (Taar1m1J) segregates  with high MA drinking and low sensitivity with MA-induced  aversion. These results suggest that increased activation  of NMDA receptors is important for aversive effects of MA.  Sensitivity to MA-induced aversion via TAAR1 signaling may  play an important protective role against developing MA use  disorders.},
      number = {IR},
      doi = {https://doi.org/10.6083/5h73pw83x},
      recid = {9250},
      address = {2021},
}