TY  - GEN
N2  - The CDC reports that 52.9% of people who used MA in the last year have a MA use disorder. Quantitative trait locus mapping in selectively bred high and low MA drinking (MADR) mouse lines identified a single nucleotide polymorphism (SNP) that accounts for 60% of the genetically determined differences in MA intake in the MADR lines. This nonsynonymous substitution mutation within the trace amine-associated receptor 1 (Taar1) gene alters the protein amino acid sequence and results in the expression of a nonfunctional TAAR1 receptor. MA is a full TAAR1 agonist, and homozygosity for this mutation (Taar1m1J) segregates with high MA drinking and low sensitivity with MA-induced aversion. These results suggest that increased activation of NMDA receptors is important for aversive effects of MA. Sensitivity to MA-induced aversion via TAAR1 signaling may play an important protective role against developing MA use disorders.
DO  - 10.6083/5h73pw83x
DO  - DOI
AB  - The CDC reports that 52.9% of people who used MA in the last year have a MA use disorder. Quantitative trait locus mapping in selectively bred high and low MA drinking (MADR) mouse lines identified a single nucleotide polymorphism (SNP) that accounts for 60% of the genetically determined differences in MA intake in the MADR lines. This nonsynonymous substitution mutation within the trace amine-associated receptor 1 (Taar1) gene alters the protein amino acid sequence and results in the expression of a nonfunctional TAAR1 receptor. MA is a full TAAR1 agonist, and homozygosity for this mutation (Taar1m1J) segregates with high MA drinking and low sensitivity with MA-induced aversion. These results suggest that increased activation of NMDA receptors is important for aversive effects of MA. Sensitivity to MA-induced aversion via TAAR1 signaling may play an important protective role against developing MA use disorders.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - The role of Lateral Habenula inputs onto Dorsal Raphe serotonin neurons in regulating methamphetamine induced aversion
DA  - 2021
AU  - Rios, Samantha
AU  - Ingram, Susan
AU  - Phillips Richards, Tamara
L1  - https://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2021
ID  - 9250
L4  - https://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
KW  - Methamphetamine
KW  - Genetics
KW  - Serotonin
KW  - Dopaminergic Neurons
KW  - Substance-Related Disorders
KW  - Behavior, Addictive
KW  - circuitry
TI  - The role of Lateral Habenula inputs onto Dorsal Raphe serotonin neurons in regulating methamphetamine induced aversion
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
ER  -