000009250 001__ 9250
000009250 005__ 20240418082825.0
000009250 0247_ $$2DOI$$a10.6083/5h73pw83x
000009250 037__ $$aIR
000009250 041__ $$aeng
000009250 245__ $$aThe role of Lateral Habenula inputs onto Dorsal Raphe serotonin neurons in regulating methamphetamine induced aversion
000009250 260__ $$bOregon Health and Science University
000009250 269__ $$a2021
000009250 336__ $$aAbstract
000009250 520__ $$aThe CDC reports that 52.9% of people who used MA in the last year have a MA use disorder. Quantitative trait locus mapping in selectively bred high and low MA drinking (MADR) mouse lines identified a single nucleotide polymorphism (SNP) that accounts for 60% of the genetically determined differences in MA intake in the MADR lines. This nonsynonymous substitution mutation within the trace amine-associated receptor 1 (Taar1) gene alters the protein amino acid sequence and results in the expression of a nonfunctional TAAR1 receptor. MA is a full TAAR1 agonist, and homozygosity for this mutation (Taar1m1J) segregates with high MA drinking and low sensitivity with MA-induced aversion. These results suggest that increased activation of NMDA receptors is important for aversive effects of MA. Sensitivity to MA-induced aversion via TAAR1 signaling may play an important protective role against developing MA use disorders.
000009250 540__ $$fCC BY
000009250 542__ $$fIn copyright - joint owners
000009250 650__ $$aMethamphetamine$$022135
000009250 650__ $$aGenetics$$019472
000009250 650__ $$aSerotonin$$025891
000009250 650__ $$aDopaminergic Neurons$$039537
000009250 650__ $$aSubstance-Related Disorders$$032029
000009250 650__ $$aBehavior, Addictive$$029367
000009250 6531_ $$acircuitry
000009250 691__ $$aSchool of Medicine$$041369
000009250 692__ $$aDepartment of Behavioral Neuroscience$$041394
000009250 7001_ $$aRios, Samantha$$uOregon Health and Science University$$041354
000009250 7001_ $$aIngram, Susan$$uOregon Health and Science University$$041354
000009250 7001_ $$aPhillips Richards, Tamara$$uOregon Health and Science University$$041354
000009250 711__ $$aResearch Week$$uOregon Health and Science University$$d2021
000009250 8564_ $$9cc31bb85-35c4-4aeb-a2d7-d609c05a2a80$$s132461$$uhttps://digitalcollections.ohsu.edu/record/9250/files/Rios-Samantha-OHSU-ResearchWeek-2021.pdf
000009250 905__ $$a/rest/prod/5h/73/pw/83/5h73pw83x
000009250 980__ $$aResearch Week