000009267 001__ 9267
000009267 005__ 20231129124949.0
000009267 0247_ $$2DOI$$a10.6083/d217qq29j
000009267 037__ $$aETD
000009267 245__ $$aFunctional roles for postsynaptic α2δ-2 proteins in Purkinje cells
000009267 260__ $$bOregon Health and Science University
000009267 269__ $$a2021
000009267 336__ $$aDissertation
000009267 502__ $$bPh.D.
000009267 520__ $$aα2δ proteins (CACNA2D1-4) are auxiliary subunits to voltage-gated calcium channels (VGCCs), and they contribute to VGCC trafficking to the plasma membrane. However, there is now evidence that their roles extend beyond VGCC-dependent function in neurons1. In fact, α2δ-1 promotes excitatory synapse formation in a calcium-independent manner. However, little is known about the potential functional redundancies of α2δ isoforms, or whether they operate pre- or postsynaptically. Thus, we investigated postsynaptic functions of the α2δ-2 proteins (CACNA2D2) in two studies.
000009267 542__ $$fIn copyright - single owner
000009267 650__ $$aCalcium Channels$$028229
000009267 650__ $$aEgtazic Acid$$018254
000009267 650__ $$aProtein Isoforms$$032074
000009267 650__ $$aPurkinje Cells$$024938
000009267 691__ $$aSchool of Medicine$$041369
000009267 692__ $$aVollum Institute$$041509
000009267 7001_ $$aBeeson, Kathleen A.
000009267 8564_ $$973b76066-bfe6-4af8-a862-524119adb8da$$s3692275$$uhttps://digitalcollections.ohsu.edu/record/9267/files/Beeson.Kathleen.2021.pdf
000009267 905__ $$a/rest/prod/d2/17/qq/29/d217qq29j
000009267 909CO $$ooai:digitalcollections.ohsu.edu:9267$$pstudent-work
000009267 980__ $$aTheses and Dissertations