000000927 001__ 927
000000927 005__ 20260120144840.0
000000927 0247_ $$2DOI$$a10.6083/M4TQ5ZKM
000000927 037__ $$aETD
000000927 245__ $$aRegulation of VEGF by TEAD4 and HIF-1α in murine oxygen-induced retinopathy
000000927 260__ $$bOregon Health and Science University
000000927 269__ $$a2013
000000927 336__ $$aDissertation
000000927 502__ $$bPh.D.
000000927 502__ $$gNeuroscience
000000927 520__ $$aRetinopathies, including diabetic retinopathy, age-related macular degeneration, and retinopathy of prematurity, are leading causes of blindness in the U.S. and involve pathological neovascularization driven by VEGF. While VEGF regulation is classically attributed to Hypoxia Inducible Factor (HIF), we identify TEAD4 as a novel regulator. Using a murine oxygen-induced retinopathy model and Müller glia-like cell lines, we show TEAD4 activates VEGF promoters in both mouse and human, with enhanced activity under hypoxia via indirect modulation of HIF1α. TEAD4 expression in neovascular tufts suggests its role in retinal angiogenesis, highlighting TEAD4 as a potential therapeutic target for neovascular eye disease.
000000927 540__ $$fCC BY
000000927 542__ $$fIn copyright - single owner
000000927 650__ $$aRetina$$025387
000000927 650__ $$aRetinal Diseases$$025391
000000927 650__ $$aHypoxia-Inducible Factor 1$$037010
000000927 650__ $$aTranscription Factors$$027255
000000927 650__ $$aVascular Endothelial Growth Factors$$035188
000000927 650__ $$aBlindness$$015641
000000927 650__ $$aRetinopathy of Prematurity$$025405
000000927 650__ $$aMacular Degeneration$$021737
000000927 650__ $$aHypoxia$$014810
000000927 650__ $$aVascular Endothelial Growth Factor A$$035189
000000927 650__ $$aDiabetic Retinopathy$$017681
000000927 6531_ $$aanoxia
000000927 6531_ $$aanoxemia
000000927 691__ $$aSchool of Medicine$$041369
000000927 692__ $$aVollum Institute$$041509
000000927 7001_ $$aCargill, Robert$$uOregon Health and Science University$$041354
000000927 7201_ $$aAppukuttan, Binoy$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000927 7201_ $$aStout, Tim$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000927 8564_ $$970371628-24b2-4e07-853c-63eede9c27c8$$s10183966$$uhttps://digitalcollections.ohsu.edu/record/927/files/930_etd.pdf$$ePublic$$2f627ecef543ca6a1341ea75d950c3a2a$$31
000000927 905__ $$a/rest/prod/cr/56/n1/06/cr56n106c
000000927 909CO $$ooai:digitalcollections.ohsu.edu:927$$pstudent-work
000000927 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000927 980__ $$aTheses and Dissertations