TY  - GEN
N2  - Tendons are an essential tissue that join together and transmit force between muscle and bone. While much is known about muscle and skeletal growth mechanisms, remarkably little is known about the induction and regulation of tendon growth. Failure of the muscle-tendon unit (MTU) to accommodate skeletal growth can result in reduced joint mobility called contractures, a common impairment in a variety of juvenile orthopedic conditions. Joint contractures are often treated by surgical lengthening of the tendon; however, this approach frequently results in tendon scarring and a recurrence of the contracture. This recurrence may be a symptom of impaired tendon development in growing children following surgery. Innovative mechanisms of tendon elongation are necessary to improve outcome. This dissertation project aimed to find key signals and processes that direct tendon elongation during development.
DO  - 10.6083/8g84mm861
DO  - DOI
AB  - Tendons are an essential tissue that join together and transmit force between muscle and bone. While much is known about muscle and skeletal growth mechanisms, remarkably little is known about the induction and regulation of tendon growth. Failure of the muscle-tendon unit (MTU) to accommodate skeletal growth can result in reduced joint mobility called contractures, a common impairment in a variety of juvenile orthopedic conditions. Joint contractures are often treated by surgical lengthening of the tendon; however, this approach frequently results in tendon scarring and a recurrence of the contracture. This recurrence may be a symptom of impaired tendon development in growing children following surgery. Innovative mechanisms of tendon elongation are necessary to improve outcome. This dissertation project aimed to find key signals and processes that direct tendon elongation during development.
T1  - Regulation of tendon elongation in development
DA  - 2021
AU  - Schlesinger, Saundra Y.
L1  - https://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9279
L4  - https://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
KW  - Contracture
KW  - Tendons
KW  - Growth and Development
KW  - Biomechanical Phenomena
KW  - Smad4 Protein
KW  - mouse
TI  - Regulation of tendon elongation in development
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
ER  -