000009279 001__ 9279
000009279 005__ 20240124114319.0
000009279 0247_ $$2DOI$$a10.6083/8g84mm861
000009279 037__ $$aETD
000009279 245__ $$aRegulation of tendon elongation in development
000009279 260__ $$bOregon Health and Science University
000009279 269__ $$a2021
000009279 336__ $$aDissertation
000009279 502__ $$bPh.D.
000009279 520__ $$aTendons are an essential tissue that join together and transmit force between muscle and bone. While much is known about muscle and skeletal growth mechanisms, remarkably little is known about the induction and regulation of tendon growth. Failure of the muscle-tendon unit (MTU) to accommodate skeletal growth can result in reduced joint mobility called contractures, a common impairment in a variety of juvenile orthopedic conditions. Joint contractures are often treated by surgical lengthening of the tendon; however, this approach frequently results in tendon scarring and a recurrence of the contracture. This recurrence may be a symptom of impaired tendon development in growing children following surgery. Innovative mechanisms of tendon elongation are necessary to improve outcome. This dissertation project aimed to find key signals and processes that direct tendon elongation during development.
000009279 542__ $$fIn copyright - single owner
000009279 650__ $$aContracture$$017073
000009279 650__ $$aTendons$$026832
000009279 650__ $$aGrowth and Development$$036136
000009279 650__ $$aBiomechanical Phenomena$$015572
000009279 650__ $$aSmad4 Protein$$037054
000009279 6531_ $$amouse
000009279 691__ $$aSchool of Medicine$$041369
000009279 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000009279 7001_ $$aSchlesinger, Saundra Y.
000009279 8564_ $$9eaf5f636-91a8-469b-bf1c-030a7c72b8f9$$s4781907$$uhttps://digitalcollections.ohsu.edu/record/9279/files/Schlesinger.Saundra.2021.pdf
000009279 905__ $$a/rest/prod/8g/84/mm/86/8g84mm861
000009279 909CO $$ooai:digitalcollections.ohsu.edu:9279$$pstudent-work
000009279 980__ $$aTheses and Dissertations