000009283 001__ 9283 000009283 005__ 20260120144920.0 000009283 0247_ $$2DOI$$a10.6083/pz50gw768 000009283 037__ $$aETD 000009283 245__ $$aThe role of dystroglycan in interneuron development 000009283 260__ $$bOregon Health and Science University 000009283 269__ $$a2021 000009283 336__ $$aDissertation 000009283 502__ $$bPh.D. 000009283 502__ $$gNeuroscience 000009283 520__ $$aThe brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons that occurs at special cellular junctions called synapses. During brain development, distinct types of neurons must identify each other to form synaptic connections. In this dissertation, I use mouse genetic tools to study the role of dystroglycan at inhibitory synapses in the forebrain. I show that CCK+ interneurons are present in the brains of mice that lack dystroglycan from the nervous system, but their axons are distributed abnormally in the hippocampus. These findings have important implications for understanding the molecular mechanisms that neurons use to wire together during brain development. 000009283 542__ $$fIn copyright - single owner 000009283 650__ $$aInterneurons$$020936 000009283 650__ $$aApoptosis$$029778 000009283 650__ $$aDystroglycans$$036156 000009283 650__ $$aAxons$$015276 000009283 650__ $$aSynapses$$026704 000009283 691__ $$aSchool of Medicine$$041369 000009283 692__ $$aVollum Institute$$041509 000009283 7001_ $$aMiller, Daniel S.$$uOregon Health and Science University$$041354$$10000-0001-5927-4397 000009283 7201_ $$aWright, Kevin$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000009283 7201_ $$aNechiporuk, Alex$$uOregon Health and Science University$$041354$$7Personal$$eCommittee chair 000009283 7201_ $$aSchnell, Eric$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000009283 7201_ $$aCopenhaver, Philip$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000009283 7201_ $$aLogan, Mary$$uOregon Health and Science University$$041354$$7Personal$$eCommittee member 000009283 8564_ $$93a84a0a5-6430-469b-87b4-e88805dd82b8$$s64138599$$uhttps://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf$$ePublic$$2684fd2fa579c3ac49ddabd7abcffe9b2$$31 000009283 905__ $$a/rest/prod/pz/50/gw/76/pz50gw768 000009283 909CO $$ooai:digitalcollections.ohsu.edu:9283$$pstudent-work 000009283 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument 000009283 980__ $$aTheses and Dissertations